磷酸曲西立濱是一種蛋白激酶B抑制劑。它有可能用于治療卵巢癌和乳腺癌。

產(chǎn)品性質(zhì)：

CAS No.：61966-08-3

別名：VQD 002, PTX200, VQD002, PTX 200, PTX-200, VQD-002

分子量：400.28

分子式：C13H17N6O7P

存儲(chǔ)：Powder: -20°C for 3 years　|　In solvent: -80°C for 2 years

溶解度：DMSO: Soluble( < 1 mg/mL refers to the product slightly soluble or insoluble )

注意事項(xiàng)：

為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并戴一次性手套操作。

Reference:

1. Garrett CR, Coppola D, Wenham RM, Cubitt CL, Neuger AM, Frost TJ, Lush RM, Sullivan DM, Cheng JQ, Sebti SM. Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT. Invest New Drugs. 2011 Dec;29(6):1381-9. doi: 10.1007/s10637-010-9479-2. PubMed PMID: 20644979; PubMed Central PMCID: PMC4612514.

2. Kim R, Yamauchi T, Husain K, Sebti S, Malafa M. Triciribine Phosphate Monohydrate, an AKT Inhibitor, Enhances Gemcitabine Activity in Pancreatic Cancer Cells. Anticancer Res. 2015 Sep;35(9):4599-604. PubMed PMID: 26254348.

3. Sampath D, Malik A, Plunkett W, Nowak B, Williams B, Burton M, Verstovsek S, Faderl S, Garcia-Manero G, List AF, Sebti S, Kantarjian HM, Ravandi F, Lancet JE. Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies. Leuk Res. 2013 Nov;37(11):1461-7. doi: 10.1016/j.leukres.2013.07.034. PubMed PMID: 23993427; PubMed Central PMCID: PMC4205589.

4. Moore EC, Hurlbert RB, Boss GR, Massia SP. Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989 Nov 15;38(22):4045-51. PubMed PMID: 2480792.