PJ34是聚(ADP-核糖)聚合酶(一種參與DNA修復(fù)和細(xì)胞增殖的酶)的新型有效抑制劑，其在無(wú)細(xì)胞測(cè)定中劑量依賴性地抑制純化的PARP酶，其半最大有效濃度EC50值為20 nM。與其他PARP抑制劑(如3-AB)不同，PJ34不具有任何抗氧化特性，但表現(xiàn)出比3-AB大10，000倍的PARP抑制作用(EC50 = 200微米)。已經(jīng)發(fā)現(xiàn)PJ34在幾種腫瘤類型中具有神經(jīng)保護(hù)作用并增強(qiáng)化療效果。研究結(jié)果表明，PJ34抑制過(guò)亞硝酸根誘導(dǎo)的細(xì)胞壞死，EC50值為20 nM，并劑量依賴性地抑制HepG2細(xì)胞的生長(zhǎng)。

產(chǎn)品性質(zhì)：

Cas No.：344458-15-7

別名：PJ 34 Hydrochloride

化學(xué)名：2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;hydrochloride

Canonical SMILES：CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl

分子式：C17H17N3O2.HCl

分子量：331.8

溶解度：≥ 16.6 mg/mL in DMSO;Water:50 mg/mL (150.69 mM)

儲(chǔ)存條件：Store at -20°C

注意事項(xiàng)：

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References：

[1].Sheng-Hui Huang, Min Xiong, Xiao-Ping Chen, Zhen-Yu Xiao, Yin-Feng Zhao and Zhi-Yong Huang. PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells. Oncology Reports 20: 567-572, 2008

[2].Galaleldin E. Abdelkarim, Karen Gertz, Christoph Harms, Juri Katchanov, Ulrich Dirnagl, Csaba Szabo and Matthias Enders. Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. International Journal of Molecular Medicine 7: 255-260, 2001